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Sternbach's method commenced with 2-amino-5-chlorobenzophenone, which undergoes cyclocondensation with glycine ethyl ester hydrochloride to construct the benzodiazepine core. This Main is subsequently alkylated for the nitrogen during the 1-placement utilizing dimethyl sulfate in the existence of sodium methoxide and methanol less than reflux ailments.
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Libervant is usually a buccally, or inside the cheek, administered movie formulation of diazepam, a benzodiazepine supposed for your acute treatment of intermittent, stereotypic episodes of Recurrent seizure action (
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